Nephrotic syndrome patients need to do renal puncture, nephrotic syndrome is divided into primary nephrotic syndrome and secondary nephrotic syndrome, primary nephrotic syndrome is generally caused by chronic glomerulonephritis, secondary nephrotic syndrome generally refers to hypertension, diabetes, connective tissue disease, etc., at this time can do renal puncture to clarify the diagnosis, the advantages of renal puncture is: 1, can identify nephrotic syndrome is primary or secondary, through renal puncture can further clarify the pathological type of nephrotic syndrome is primary or secondary. The advantages of kidney puncture are: 1) to identify whether nephrotic syndrome is primary or secondary, through kidney puncture can further clarify whether nephrotic syndrome is primary or secondary. 2) to clarify the pathological type of nephrotic syndrome, the pathological type of nephrotic syndrome is divided into microscopic lesion type, membrane type, membrane hyperplasia type, etc., through kidney puncture can clarify the diagnosis. 3) to develop a treatment plan and judge the prognosis, through kidney puncture can clarify the pathological type, according to the pathological type to develop a treatment plan and Judgment of prognosis, such as micro lesion type, the application of hormone and other treatment effect is better, the prognosis is also better.