Valsartan hydrochlorothiazide tablets can be combined with calcium channel blockers, beta receptor antagonists and other drugs to lower blood pressure. Clinically, this product belongs to the compound preparation drug of valsartan and hydrochlorothiazide. After taking it, it can reduce the extracellular volume, reduce peripheral vascular resistance, as well as block the vasoconstrictive effect of angiotensin II receptor, so as to play the role of lowering blood pressure; mainly used for the treatment of mild and moderate essential hypertension. If the drug cannot achieve the desired effect of lowering blood pressure, it can be combined with β-receptor antagonists, calcium channel blockers and other drugs, such as metoprolol, amlodipine, etc., which can inhibit myocardial contractility and slow down the heart rate, as well as reduce peripheral vascular resistance, so as to play a stronger and more long-lasting effect of lowering blood pressure. The drug may cause cough, nausea, diarrhea, headache and other discomforts after taking it; it is contraindicated for those who are allergic to the components of the drug or sulfonamide derivatives, severe liver failure, biliary cirrhosis, severe renal failure, refractory hypokalemia, hyponatremia; at the same time, it is necessary to pay attention to the monitoring of electrolytes, liver and renal function, etc., and for the special groups such as pregnant women, children, the elderly and other special groups, the need to use the drug under the guidance of a doctor. If the treatment of valsartan hydrochlorothiazide tablets does not achieve the desired effect of lowering blood pressure, it is recommended that after a comprehensive assessment by a doctor to choose with other antihypertensive drugs for treatment.