Tuberculosis is caused by tuberculosis bacilli invading the lungs and causing lung infections, usually does not appear itchy skin, itchy skin is most likely because the skin is subjected to other stimuli, it is recommended to go to the dermatology hospital to carry out a specific examination. Patients with tuberculosis are now mainly treated with drugs, including pyrazinamide, rifampicin, ethambutol, etc., but different anti-tuberculosis drugs will have different side effects. When patients have itchy skin after using anti-tuberculosis drugs, the main reason may be the combined effect of isoniazid, ethambutol and rifampicin, causing severe drug skin allergic reaction, and there will be a large area of rash accompanied by the patient will also have severe scratching, and if the situation is serious, patients will also have skin infections and so on. Tuberculosis drug-induced severe dermatosis, known as drug hypersensitivity syndrome, this type of patient if the reaction is more serious, will endanger the patient’s life. The specific situation needs to consult a professional doctor, by the doctor’s guidance to do the next step in the treatment.