Children in the middle of the night toothache should be the emergence of acute pulpitis, you can choose to mouth cool water, oral painkillers, open pulp drainage and other treatment measures. 1. Oral cool water: acute pulpitis in addition to night pain, there will be hot and cold stimulation aggravation, oral cool water can relieve the pain symptoms. 2. Oral painkillers: Acute pulpitis can also be prescribed oral ibuprofen granules or ibuprofen suspension to relieve pain. 3. Open pulp drainage: the most thorough way to treat acute pulpitis is to open the pulp drainage, which can quickly reduce the pressure of the tooth pulp cavity, thus relieving tooth pain. Children with tooth pain should not blindly use their own medication, and promptly go to a regular hospital, under the advice of a professional physician to choose the best treatment plan to reduce the child’s pain.