Interferon is a glycoprotein produced by the lymphocytes and macrophages in the human immune system under the action of viral stimulation or interferon-inducing agents, which has a generalized antiviral effect, mainly in two aspects: inhibition of virus replication and release of the remaining inhibition of the replication of infected cells. Interferon is currently one of the effective drugs for the treatment of viral hepatitis, there are two types of interferon, ordinary interferon and long-acting interferon, long-acting interferon is attached to the molecule of ordinary interferon pegylated glycol molecules, so that the pegylated glycol molecules form a molecular barrier outside the interferon molecule, reducing the immunogenicity of interferon, and make it free from enzymatic decomposition, extending the half-life, that is, extending its action time, reducing the dosing This makes it more convenient for patients to use. However, despite the great achievements in the treatment of viral hepatitis, the adverse effects of both regular and long-acting interferons have caused a lot of suffering. The common adverse reactions of interferon and treatment measures are introduced in detail. 1, flu-like syndrome This is the most common adverse reactions, including fever? , chills, sweating, headache, dizziness, weakness, muscle and joint pain and other uncomfortable symptoms. Fever is the most common adverse reaction, usually occurs on the first day after the drug, especially after 4-5 hours after the intramuscular injection of body temperature began to rise, 6-9 hours to reach a peak, usually lasting 4-12 hours to subside, but some cases can be prolonged fever, and some can even last until the end of the course of treatment or termination of treatment. Body temperature generally fluctuates between 37℃-38℃, with the highest temperature reaching 40℃. The fever gradually disappears with the prolongation of the treatment course. In addition to infection, physical cooling can be used, such as ice pillows, warm water baths, alcohol baths, etc. If necessary, oral aspirin, acetaminophen or other non-steroidal anti-inflammatory drugs can be given to lower the body temperature to below 38℃ and reduce the patient’s psychological burden to ensure that the treatment proceeds smoothly as planned. For discomfort such as headache, dizziness, weakness and muscle and joint pain, observation, massage and symptomatic treatment can be given. In addition to this, more communication should be made with the patient to reduce the patient’s concern about the application of interferon therapy. Such syndrome is related to the type and dose of interferon used. Long-acting interferon is more obvious, the higher the applied dose, the stronger the reaction, the higher the incidence. 2, gastrointestinal symptoms mainly manifested as dry mouth, mouth ulcers, stomatitis, loss of appetite, nausea, vomiting, abdominal distension, constipation and other uncomfortable symptoms unrelated to the original disease, patients with such symptoms, should be arranged according to the patient’s preferred taste diet, a small number of meals, to ensure a good dining environment, improve appetite, which helps to ensure the patient’s nutritional supply. If necessary, give symptomatic treatment such as metoclopramide hydrochloride injection, domperidone tablets and pantoprazole sodium enteric capsule. 3, allergic reactions Clinical manifestations are mostly urticaria, maculopapular rash, herpes of the mouth and lips, the average time of occurrence of the reaction is short, individual patients have allergic reactions after the first dose. Pay attention to the site, extent and accompanying symptoms of the rash, avoid rubbing, avoid scratching with hands, cold compress, apply anti-allergic drugs according to the situation, the symptoms of mild or transient rash does not affect the treatment of interferon, serious acute allergic reactions (including urticaria, angioedema, bronchospasm and anaphylaxis) need to stop the drug and anti-allergic and symptomatic treatment, therefore, allergic patients should be used with caution, the use of drugs Therefore, it should be used with caution and observed for a period of time after use. Studies have shown that interferon has a mild to moderate myelosuppressive effect, which is usually attributed to the reversible inhibitory effect of interferon on bone marrow hematopoiesis and the reversible blockage of leukocyte release from the bone marrow, which is also believed to be the result of distribution changes in the body. The statistical analysis found that about 20% of patients may experience a mild to moderate decrease in total leukocyte count, neutrophil count and platelet count, therefore, the leukocyte count should be routinely monitored during the application of interferon. If necessary, recombinant human granulocyte-macrophage colony-stimulating factor can be considered as immunotherapy. These patients should avoid going to crowded places to prevent fulminant infection and actively prevent colds. Leukocytes