Atrophic gastritis with intestinal metaplasia is a precancerous condition, and without aggressive treatment and early intervention, the chances of the disease becoming cancerous are usually around 60%. Since the disease is closely related to Helicobacter pylori infection, treatment of the disease as well as prevention of cancer usually requires anti-Helicobacter pylori treatment, regular gastroscopy and early surgical resection. Anti-Helicobacter pylori treatment is currently a quadruple therapy consisting of two antibiotics, such as metronidazole and amoxicillin, a proton pump inhibitor, such as lansoprazole, and a bismuth agent, such as bismuth potassium citrate. Regular use under a doctor’s supervision will usually eradicate H. pylori. Along with active medication, regular gastroscopy should be observed to monitor the progress of the lesion site. If you find that the medication is not effective, you can contact your doctor to adjust the medication. If the lesion is found to have deterioration or early gastric cancer, since the tumor has not yet metastasized and spread, it can be surgically removed, and usually can be cured. Atrophic gastritis with intestinal metaplasia has the possibility of cancer, so you should consult a doctor in time, improve the examination and standardize the treatment under the doctor’s guidance.