Drugs for treating male premature ejaculation include 5-hydroxytryptamine reuptake inhibitors, local surface anesthetics and so on. 1. 5-hydroxytryptamine reuptake inhibitors: commonly used drugs include dapoxetine, citalopram, paroxetine, sertraline, etc. By inhibiting the reuptake of 5-hydroxytryptamine in the brain’s neurotransmitters and increasing the 5-hydroxytryptamine in the interstitial space of the tissues, the sensitivity and impulse to ejaculation of the patient are reduced, so as to achieve the purpose of delaying ejaculation. 2. Local surface anesthetics: including lidocaine, proparacaine, benzocaine, etc., through local anesthesia of the epidermis of the penis, reduce penile sensitivity, slow down the incoming ejaculation impulse, thus prolonging the ejaculation time. If there is a need for medicine, the above drugs must be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.