Diabetic microcirculatory disorders generally refer to microcirculatory disorders caused by diabetes-related factors, which can cause microcirculatory ischemia and hypoxia, and then lead to organ dysfunction, including diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, and diabetic foot.
The exact pathogenesis of diabetic microcirculatory disorders has not been fully elucidated, but mainly involves functional and metabolic abnormalities such as damage to the vascular endothelium and reduction of nitric oxide synthesis, activation of the polyol pathway, non-enzymatic glycation of proteins, oxidative stress, and protein kinase C activation.
In the presence of diabetic microcirculatory disorders, strict glycemic control is required in addition to treatment of the lesion itself. Patients with diabetic microcirculatory disorders are advised to go to the hospital for treatment under the guidance of a doctor.