Intestinal wall thickening is only superficial. The so-called intestinal wall thickening is usually found through ultrasound, CT, and gastrointestinal imaging, which reveals that a certain section of the intestinal wall is thicker and thicker than the normal one. There are many reasons for the thickening and thickening of the intestinal wall, including inflammatory stimulation, ulcer formation, chronic ischemia, and the formation of tumors. A more accurate diagnosis of the specific cause of intestinal wall thickening is needed. If thickening of the gastric lumen or thickening of the intestinal wall is suspected, a small ultrasonography or a full gastroscopy is required. If the cause still cannot be identified, there are more precise methods such as capsule endoscopy that provide a more definitive diagnosis. Therefore, whenever a patient’s examination suggests symptoms of intestinal wall thickening, he or she needs to see a specialist for the appropriate specialized tests to clarify the cause.