Hepatitis B antiviral treatment for ten years belongs to the chronic viral hepatitis B, generally is very difficult to completely cure, may need long-term medication. At the same time, it should be prevented from causing heavy hepatitis, sludge hepatitis, hepatitis cirrhosis and other conditions. Chronic viral hepatitis B is a disease with a long duration and infectious. Treatment mainly includes antiviral therapy, immunomodulation, anti-inflammatory liver protection, anti-fibrosis and symptomatic treatment. At present, chronic viral hepatitis B is difficult to be completely cured, and there is a possibility of recurrence, but it is not impossible to cure. At the same time, patients should actively prevent chronic viral hepatitis B caused by severe hepatitis, hepatitis silt type, hepatitis cirrhosis, hepatocellular carcinoma and other conditions. Patients should follow the doctor’s instructions for regular review and follow-up, and need to be examined once every 1~3 months after the condition is stabilized.