If it is caused by neurasthenia, you can take glutamine, tranquilize the brain liquid, nourish blood and clear brain particles to regulate sleep. If it is caused by anxiety, you can take tandospiroxone, buspirone, lorazepam. If it is caused by depression, you can take oral Derexin, citalopram, mirtazapine and other drugs. If the patient has a somatic disease caused by physical discomfort, resulting in sleeplessness, the main treatment of the primary disease, such as headache may cause the patient sleeplessness when severe, you can use some symptomatic pain medication, such as oral ibuprofen, indomethacin and naproxen and so on. Patients with neuralgia can also cause sleeplessness, usually oral carbamazepine and so on.