Creatinine values in stage 3 chronic kidney disease range from 176 μmol/L to 441 μmol/L. Chronic kidney disease can be classified into 5 stages based on the values of glomerular filtration rate. The value of endogenous creatinine clearance is used clinically to reflect the glomerular filtration rate, and creatinine clearance is generally estimated from the value of blood creatinine, so the range of blood creatinine value is also generally correlated with the stage of kidney disease. Most patients with stage 3 nephropathy have no obvious clinical symptoms, and some of them can be accompanied by mild weakness, loss of appetite, nausea and vomiting. In addition, clinically nephropathy can also be staged according to the value of glomerular filtration rate. The glomerular filtration rate in stage 3a ranges from 45-59 ml/min, while that in stage 3b ranges from 30-44 ml/min.