Hepatitis B 145 positive, also known as Hepatitis B Minor Triple Positive, is a disease that usually resolves itself in a small percentage of patients. Hepatitis B is a relatively common infectious disease and is also a difficult disease to treat, but there are still a small number of cases where clinical spontaneous recovery can occur. 145-positive, also known as Hepatitis B Minor Triple Yang, can be an active liver disease or a more stable state. In the long term, if there is no significant liver inflammation, no specific treatment is needed. During long-term follow-up, there may be a gradual decrease in surface antigen, further indicating antigenic turnover, leading to spontaneous healing. However, the chances of this happening are relatively low, and some people achieve the effect of turning negative through long-term antiviral treatment. Therefore, we should still pay attention to the clinical management of Hepatitis B Triple III, and strive to better promote the recovery of the disease, and achieve the clinical cure of Hepatitis B Triple III through standardized treatment in accordance with the doctor’s instructions.