Whether NSAIDs can be taken for a long period of time is related to the type of disease, most of them cannot be taken for a long period of time, but some patients with rheumatic immune diseases may need to take them for a long period of time under the guidance of a doctor. NSAIDs refer to celecoxib, meloxicam, diclofenac sodium, etc. They are often used to relieve mild or moderate pain, and the effects are more pronounced after taking them, and there is generally no dependence on them when they are taken for a long period of time. However, long-term use of NSAIDs may lead to some adverse reactions, mainly gastrointestinal reactions and neurological reactions, but also some patients will have blood system reactions, so no special circumstances generally do not recommend long-term use. However, some patients with rheumatic immune diseases, such as rheumatoid arthritis, may need long-term medication in order to control their conditions. Patients must follow the doctor’s instructions to use the drug, do not use the drug arbitrarily on their own, so as not to cause unnecessary damage.