How to distinguish low, intermediate and high risk of breast cancer? ( l ) Definition of low risk: negative axillary lymph nodes with all of the following features: lesion size (pT) ≤ 2 cm in the specimen, pathological grade 1, no invasion of peripheral tumor vessels, HER -2 (-), age > 35 years. Chemotherapy regimen can be chosen: CMF *6 or AC / EC*( 4 -6 ). ( 2 ) Definition of moderate risk: ① Negative axillary lymph nodes with at least one of the following features: lesion size (pT) > 2 cm in the specimen, pathological grading of grade 2 – 3, invasion of tumor peripheral vessels, HER -2 gene overexpression or amplification, and age < 35 years. ② Axillary lymph node micrometastasis (LNM) 1-3 and HER -2 (-). The options are FAC / FEC 6. ( 3 ) High risk is defined as: ① axillary lymph node micrometastasis (LNM) 1-3 and HER-2 (+); ② axillary LNM > 3. The options are: ACoT (AC sequential paclitaxel), FEC x 3oT x 3 (FEC sequential doxorubicin), TAC (doxorubicin bing doxorubicin/cyclophospholipid), A ascending ToC. It is also possible to use fortnightly dose intensive chemotherapy with G-CSF support, ddAC x4 * ddT x4; or ddA * ddToddC (doxorubicin sequential paclitaxel sequential cyclophosphopyramide).