Toothache is often caused by tooth decay, periodontitis, endodontic disease, etc. It can be treated at home first to relieve pain, such as warm water rinsing mouth, hot compress on cheek, etc., and then seek medical examination as soon as possible, according to the cause of targeted treatment. First, general treatment: Most toothaches need to be treated with medication under the guidance of a doctor, depending on the cause. For example, if the pain is severe, you can use ibuprofen or acetaminophen to relieve pain; if the infection is clear after examination, you can use chlorhexidine rinse, or take oral antibiotics such as roxithromycin and metronidazole. 2.Causal treatment: 1.Caries: Firstly, remove the decayed part, then fill it with resin, if the degree of caries is mild, you can also use chemotherapy. As long as the carious part is avoided to stimulate the tooth nerve, the toothache can be eliminated; 2, pulp disease: If the dentin or root lesion is serious and causes pulpitis, it is more serious and may need to open the pulp and drainage or surgical treatment. Commonly, there is root canal treatment, which means removing the pulp and preserving the rest of the tooth; 3, other diseases: trigeminal neuralgia may also cause the sensation of toothache, which needs to be treated according to the cause, and can be treated with closure therapy or injection therapy, or surgery if necessary.