Due to the different types of antihypertensive drugs, long-term use will have different side effects, such as irritating dry cough, increased or decreased blood potassium, increased blood creatinine, angioedema, bradycardia, decreased blood pressure, headache, ankle edema and so on. 1. Angiotensin receptor antagonists, such as captopril tablets, have a common side effect of irritating dry cough, and some patients also experience side effects such as elevated blood potassium and blood creatinine. 2. Angiotensin receptor converting enzyme inhibitors, such as valsartan capsules, may cause side effects such as elevated blood potassium and angioedema. 3. β-blockers, such as metoprolol tartrate tablets, have the effect of slowing down the heart rate, which may cause bradycardia, decreased blood pressure and aggravation of atrioventricular block. 4. Calcium channel antagonists, such as amlodipine benzenesulfonate tablets, may cause headache and ankle edema. The side effects of the above drugs usually appear when they are taken for a short period of time, and if there is no discomfort in the short term, long-term use will generally have no effect. If there is no discomfort in the short term, the type of antihypertensive drug should be changed. 5. Diuretics, such as thiazides and spironolactone, when taken for a long period of time, thiazides have the risk of hypokalemia and spironolactone has the risk of hyperkalemia. All drugs, if taken in excess, can lead to low blood pressure, hypotension and other symptoms, such as dizziness, weakness, drowsiness and so on. Be sure to choose antihypertensive drugs reasonably under the guidance of your doctor and avoid private medication.