Total cystectomy is generally a way to treat malignant tumors of the bladder, so its prognosis is related to many factors such as the patient’s age, whether it is combined with chronic diseases, whether the lymph nodes are metastatic, etc., and cannot be judged simply. The postoperative prognosis and regression of bladder cancer patients varies greatly, and there are many factors affecting the prognosis of patients, such as the age of patients, whether they are combined with chronic diseases, surgical methods, whether the ureter is invasive or not, and the time of surgery. Among them, the presence or absence of lymph node metastasis, the presence or absence of ureteral invasion and the presence or absence of involvement of the urethral stump had the most significant impact on the survival of patients. In addition, patients who underwent radical cystectomy + neoadjuvant chemotherapy had a better prognosis than those who underwent radical cystectomy alone. In contrast, an elevated tumor stage results in a relatively worse prognosis. Regular follow-up should be performed after total cystectomy to monitor changes in disease.