Based on a 5 cm occupying lesion in the tail of the pancreas, it is not possible to determine the nature of the tumor alone. Pathologic testing is needed to determine whether it is malignant or benign. When a 5 cm occupying lesion is present in the tail of the pancreas, it may be malignant or benign. Further testing is required to determine its nature. The patient may be able to determine the nature of the pancreatic tail occupancy by puncturing the site of the lesion and selecting it for pathologic examination. Patients with pancreatic tail occupancy of 5 cm in size should improve the examination in time, and when it meets the indications for surgery, the tumor site should be resected as soon as possible by means of surgery in order to achieve the purpose of treating the disease. When occupying tumors appear in the tail of pancreas, timely medical treatment should be sought to avoid aggravation of the condition.