Class 4c thyroid nodules indicate that the thyroid nodules have a greater chance of malignancy, highly suspicious of malignancy, malignancy rate of 50% to 90%, after a clear diagnosis, can be treated by surgery and drugs under the guidance of the doctor. 1. Surgical treatment: when the patient has 4c thyroid nodules, it means that the thyroid nodules in the patient’s body have a greater chance of malignant transformation, so we can consider thyroid fine needle aspiration to make a clear diagnosis, and if malignant, we need to treat it through surgical procedures in time, which generally include total thyroidectomy, lobectomy, lumpectomy, and microwave ablation. 2. Medication: If patients have hypothyroidism after surgery, they need to take long-term medication, such as levothyroxine sodium tablets, to maintain the normal level of thyroid hormones in the body. Patients with category 4c thyroid nodules are advised to go to the hospital in time, complete the relevant examinations and standardize the treatment under the guidance of the doctor.