Anti-tuberculosis medication bronzing of the hands and feet may be a common adverse reaction after prolonged use of pyrazinamide. Pyrazinamide is a commonly used antimicrobial drug for tuberculosis that kills Mycobacterium tuberculosis, and its effect is strongest at around pH 5 to 5.5. Pyrazinamide has a high incidence of side effects, commonly including loss of appetite, fever, liver impairment, arthralgia, and gastrointestinal reactions. One of the common ones is that pyrazinamide is more sensitive to light, the exposed parts of the skin can appear reddish brown, and long-term use can appear bronze color, but usually after stopping the drug can be recovered on its own, don’t worry too much. Pyrazinamide is not suitable for children under three years of age, while patients who are allergic to isoniazid, niacin and other drugs with a similar chemical structure may also be allergic to this product. It should be used with caution in diabetes, gout, as well as severe hepatic hypoplasia, and is contraindicated in pregnant women. Drugs need to be used under the guidance of a professional physician, can not be used at will, during the use of drugs should be regularly checked liver function, if there is any discomfort, you should seek medical attention as soon as possible.