Earache from high altitude to low altitude belongs to pneumatic pressure injury, which is commonly caused by middle ear pneumatic pressure injury and irritation of tympanic membrane. Those with mild symptoms can be relieved on their own, while those with obvious earache can be relieved by general treatment or medication. High altitude to low altitude, the tympanic chamber is negative pressure, if the outer mouth of the Eustachian tube is not easy to open by the surrounding high air pressure, resulting in an increase in the negative pressure in the middle ear, resulting in the dilation of the mucosal blood vessels, mucosal oedema, fluid in the tympanic chamber, the serious cases can occur in submucous hemorrhage or blood in the tympanic chamber, or cause tympanic membrane congestion, invagination, or even rupture. 1. General treatment: earache symptoms are mild, generally without special treatment can be relieved by themselves; can not be relieved by swallowing, pinching the nose and drumming method to reduce the air pressure difference between the inside and outside of the ear, to relieve the symptoms of ear pain. 2. Drug treatment: If the tympanic membrane is congested and edematous, ciprofloxacin drops or levofloxacin hydrochloride drops can be put into the ear to relieve the swelling. When the pain is severe, oral ibuprofen and diclofenac sodium can be used as anti-inflammatory and analgesic. Nasal mucosa decongestant can be used to relieve swelling of nasal mucosa and promote the opening of the Eustachian tube to relieve earache. If the symptoms of earache are obvious, not relieved for a long time or manifested by pus outflow, it is recommended to consult the ENT department in time and be given targeted treatment by specialized doctors. The above medications should be used under the guidance of a doctor.