Domperidone can be taken with most antihypertensive drugs, but not with hydrochlorothiazide. Domperidone is a drug that promotes gastric motility mainly by acting on the gastrointestinal wall, enhancing gastrointestinal peristalsis, coordinating gastric and duodenal motility, and is more effective in treating nausea, vomiting, abdominal distension, and dyspepsia. Domperidone is required to be taken orally 15-30 minutes before meals, when the food enters the stomach, the drug has begun to take effect, which can better improve the symptoms of postprandial satiety, early satiety, etc. Taking it after meals may affect the absorption of the drug, and the therapeutic effect is not obvious. Antihypertensive drugs are more varied, with the role of lowering blood pressure, dilate blood vessels, and hydrochlorothiazide is mostly required to take in the morning, mostly because most people’s blood pressure 24-hour diurnal pattern of change, the morning due to sympathetic nerve excitation, blood pressure gradually rise, so the morning immediately take antihypertensive drugs to the morning peak of the morning as far as possible to control the blood pressure better. To summarize, domperidone and antihypertensive drugs belong to two different effects of drugs, the specific time to take in strict accordance with medical advice. But domperidone in the process of taking may appear headache, dizziness, drowsiness and other adverse reactions. If the symptoms are more serious, it is recommended to consult a doctor in time. Moreover, it is forbidden for those who are allergic to domperidone or have mechanical gastrointestinal obstruction, gastrointestinal bleeding, perforation and other patients.