The choice of medication for myocardial ischemia is based on the severity of the condition, so there is no most appropriate medication. For myocardial ischemia, the most common drugs are nitrate drugs, β-receptor antagonists, calcium channel blockers and so on. 1. Nitrate drugs: Nitroglycerin and isosorbide nitrate are representative drugs. Headache, dizziness, upright hypotension or tachycardia may occur in the early stage of drug administration. Severe hypotension, anemia, glaucoma, allergy and lactating women are prohibited. 2. β-receptor antagonists: representative drugs include metoprolol, bisoprolol, etc. Adverse reactions such as fatigue, dizziness, headache, bradycardia, etc., can occur with this class of drugs. For cardiogenic shock, moderate to severe atrioventricular block, heart failure, as well as pregnant women, lactating women, allergy is prohibited. 3. Calcium channel blockers: represented by nifedipine, amlodipine and so on, this kind of drugs may cause swelling of ankles and calves, as well as headache, palpitation, blood pressure drop and other adverse reactions, low blood pressure patients should be used with caution, pregnant women, lactating mothers, severe aortic stenosis and allergy is prohibited. In addition, if myocardial ischemia is combined with high blood lipid, it is also necessary to combine lipid-lowering drugs, such as atorvastatin, fluvastatin, etc.; part of the population will also take antiplatelet aggregation drugs, such as aspirin together with the treatment. The use of the above drugs should be in accordance with medical advice, to avoid unauthorized use of discomfort.