HPV positivity with atypical squamous cells on TCT represents human papillomavirus infection and the presence of atypical squamous cells on TCT. Atypical squamous cells are cells formed by cell mutation due to inflammation of the uterine cervix and belong to the category of atypical cells, suggesting precancerous lesions. Because they are pre-cancerous lesions, the abnormal cells usually do not invade the mesenchyme and do not metastasize, so if they are detected at this time and treated accordingly, they may be cured. If not actively treated, it may develop into malignant tumors such as carcinoma in situ and invasive carcinoma. Therefore, it is recommended to perfect colposcopy and take a biopsy for pathological examination and give appropriate treatment according to the pathological results. If the pathological result of colposcopy and biopsy is mild atypical hyperplasia, pay attention to follow-up and review every six months to a year to closely monitor the development of the disease. Daily advice is to improve living and eating habits, keep a happy mood, avoid spicy and stimulating or cold foods, eat more fruits and vegetables, and exercise appropriately to improve your immunity. If the results show moderate or severe atypical hyperplasia, anti-viral treatment with drugs such as pau d’arco and interferon suppositories need to be applied under the guidance of the doctor, and laser, freezing, electro-ironing and hysterectomy can also be applied, and regular follow-up should also be noted.