You should not drink alcohol after taking colchicine. Colchicine is mainly used for the treatment of acute attacks of gouty arthritis and the prevention of acute attacks of recurrent gouty arthritis. Colchicine has large toxic side effects. The most common adverse reactions are gastrointestinal reactions such as nausea, vomiting, abdominal pain, diarrhea, etc. The incidence can reach 80%, and some patients are unable to adhere to the medication because of severe gastrointestinal reactions. Gastrointestinal reactions are the precursors of serious colchicine poisoning, and the drug should be stopped immediately when symptoms appear. Alcohol can also stimulate the mucous membrane of the gastrointestinal tract and cause nausea and vomiting, so drinking alcohol while taking colchicine can aggravate the gastrointestinal reactions, and it is not easy to determine whether the precursor symptoms of drug poisoning have appeared. Drinking alcohol can also trigger or aggravate the attack of gout, which is not conducive to the treatment of the disease. Colchicine is also more toxic to the liver and kidneys, and drinking alcohol can also aggravate the effects on the liver and kidneys, so alcohol should be avoided when taking colchicine.