The muscle pain connecting the popliteal fossa and the calf can be solved by general treatment, medication, physical therapy and surgery according to the cause, and it is considered to be caused by excessive exercise, myofasciitis and lumbar intervertebral disc herniation. 1. Excessive exercise: If lactic acid builds up after a long period of inactivity, resulting in muscle pain, there is generally no need for special treatment, and can be relieved by rest. 2. Myofasciitis: If the local myofasciitis is caused by exertion, cold, standing for a long time, it is recommended to carry out local hot compresses, massage and other physical therapy, can be used externally with diclofenac diethylamide emulsion or oral celecoxib and other non-steroidal anti-inflammatory drugs to relieve pain treatment. 3. Lumbar disc herniation: pain caused by nerve root compression due to lumbar disc herniation, it is recommended to stay in bed strictly, take anti-inflammatory drugs such as diclofenac and nutritive drugs such as methylcobalamin orally, and lumbar spine traction and acupuncture under the guidance of professionals are also feasible. Surgery to remove the protruding nucleus pulposus is necessary if conservative treatment is not effective. There are other causes of pain in the popliteal fossa and the muscles connecting the calf, such as trauma, popliteal cysts, lower limb vascular disease, etc. If it is not relieved after resting, it is recommended to go to the hospital in a timely manner, complete the relevant examinations, and carry out the corresponding treatments under the guidance of the doctor after the cause of the disease is clarified, and do not use medication and treatments on your own, so as to avoid the adverse consequences.