Desensitization therapy is a method of treating premature ejaculation, which can be effective for some patients, but the effect may not be very satisfactory for some patients, and needs to be supplemented with medication and surgical treatment under the guidance of a doctor. Desensitization therapy for premature ejaculation generally refers to behavioral therapy, that is, by giving the patient a certain amount of sexual stimulation of the penis, but not to achieve ejaculation of the patient, and then give a certain amount of sexual stimulation when the patient’s penile sensitivity is reduced, as a way of treating sensitive premature ejaculation. Commonly used methods include squeezing and pinching, move-stop method, etc., which helps patients to receive medium intensity stimulation, and progressive treatment and training. However, desensitization of premature ejaculation may not be ideal for patients with particularly high glans sensitivity, and the effect of this treatment is usually difficult to maintain long-term, need to take oral dapoxetine under the guidance of the doctor, topical lidocaine cream and other auxiliary treatment. For conservative treatment is ineffective, may also want to consider surgery, such as selective dorsal penile neurotomy. All of the above medications need to be aware of the side effects and adverse reactions of the drugs, please use the above medications under the guidance of a doctor. Surgery carries certain risks or may not be able to meet psychological expectations, and should be chosen carefully with full knowledge of the pros and cons of surgery. It is recommended that patients with sensitive premature ejaculation should undergo standardized treatment under the guidance of a doctor.