The heritability of SLE is relatively high. SLE is an autoimmune disease in which pathogenic autoantibodies and immune complexes are formed and mediate organ and tissue damage. Clinically, there is often multi-system involvement, and a variety of autoantibodies represented by antinuclear antibodies are present in the serum. SLE is an autoimmune disease, the cause of which is still unclear, and is usually related to genetic factors, hormone levels, infections, environmental factors, medications and other aspects. The number of SLE patients with first-generation relatives with SLE is higher than that of families without SLE patients, and the number of monozygotic twins with SLE is higher than that of heterozygotic twins. Clinically, SLE patients often have relatives with other connective tissue diseases in their families. Therefore, the heritability of SLE is relatively high. SLE involves many organs, commonly found in the skin, joints, kidneys, central nervous system, etc. Typical symptoms include butterfly-shaped erythema on the face, pain in the proximal interphalangeal joints, morning stiffness, etc. Laboratory tests may reveal positive antinuclear antibodies, anti-single-stranded DNA antibodies, anti-Sm antibodies, etc. If there is a family member with SLE, the patient may be born with SLE. If there is a genetic history of SLE in the family, you may choose to go to the hospital for regular screening of the antinuclear antibody profile.