Taking tilmisartan for blood pressure reduction has a more lasting effect, but Irbesartan can also be used for diabetic nephropathy combined with hypertension, with a wider range of indications. Timosartan and Irbesartan are both angiotensin-II receptor antagonists, both have vasodilatation, lowering blood pressure and so on, both can be used in the treatment of essential hypertension. In terms of lowering blood pressure, Irbesartan specification points out that the half-life of this product is 11-15 hours, while the half-life of timosartan is about 24 hours, the effect of the drug is more durable. However, Irbesartan has no effect on blood glucose, kidneys, lipids, etc. It can also treat type 2 diabetic nephropathy combined with hypertension, and the indications are broader than timosartan. Therefore, the choice of medication should be used by the doctor according to the condition. Timosartan is contraindicated in mid to late pregnancy, biliary obstructive disease, severe hepatic impairment. Adverse reactions include headache, dizziness, nausea, fatigue, weakness, cough, weakness and edema. Irbesartan is contraindicated in people who are breastfeeding, allergic to the components of the product, and who are 4 to 9 months pregnant. Adverse reactions include fatigue, chest pain, dizziness, fatigue, nausea and vomiting. It is recommended to use it under the supervision of a physician and early medical attention is recommended in case of adverse reactions.