The danger of several plus signs of urinary protein cannot be generalized and is usually related to the cause of the protein in the urine. Physiological causes are generally not dangerous, pathological causes are relatively dangerous, and those caused by large amounts of proteinuria may be more risky. Urine protein is the presence of protein in the urine. The presence of a plus sign indicates a positive urine protein. Physiological factors: consume too much meat, strenuous exercise, mental over-progress, etc., can appear urine protein, usually in the elimination of the causative factors, can gradually return to normal, generally not dangerous. Pathological factors: such as acute and chronic glomerulonephritis, urinary tract infections, stones, tumors, etc., can cause an increase in urinary protein, which is relatively dangerous at this time, and at the same time can be accompanied by other symptoms such as edema, hematuria, electrolyte disorders, etc., and the progression of the disease can lead to a decline in renal function. It is recommended that patients with increased urinary protein, go to the hospital in a timely manner, under the guidance of the doctor to improve the relevant examination, such as pathological factors, it is recommended that active treatment to avoid the development of the condition.