Lupus nephritis lower limb edema after treatment may be related to insufficient course of treatment and concomitant renal insufficiency. 1. Insufficient treatment: Lupus nephritis needs to be treated with sufficient amount of hormone (prednisone, methylprednisolone, etc.) and immunosuppressant (mertiomacrophenol ester, hydroxychloroquine, etc.), and the lower limbs may still be edematous when the treatment is insufficient, and the medication should not be discontinued at this time. 2. Accompanied by renal insufficiency: the physiological function of kidney is mainly to excrete metabolites, regulate water, electrolyte and acid-base balance, maintain the stability of the internal environment of the body and endocrine function. In patients with lupus nephritis with renal insufficiency, glomerular filtration rate decreases, tubular water and sodium reabsorption increases, and sodium retention leads to excessive blood volume, which in turn leads to lower limb edema. If the lower limbs are still edematous after the treatment of lupus nephritis, you should go to the hospital for review in time and adjust the medication under the guidance of the professional physician, and do not stop the medication on your own.