For malignant melanoma of skin, the treatment mainly includes drug therapy, surgery, chemotherapy, targeted therapy, laser therapy, biological immunotherapy and so on. 1. Drug treatment: In the early stage of melanoma, imiquimod cream can be given under doctor’s guidance, which can be directly applied to the surface of melanoma. BCG vaccine can be injected directly into the melanoma, which can play a certain therapeutic role. 2. Surgery: Most of the first choice of skin melanoma treatment is surgery. In the early stage of the disease, cure can be realized through surgical treatments such as Mohs surgery, extended excision, lymph node dissection, palliative excision and other surgical methods. 3. Chemotherapy: given chemotherapy drugs, such as paclitaxel, dacarbazine, temozolomide, albumin paclitaxel, etc., which can kill the cancer cells and also stop the growth of cancer cells. 4. Targeted therapy: Targeted drug therapy mainly includes trametinib, dabrafenib, imatinib and so on. The purpose of the treatment is to target the cancer-causing mutations. 5. Laser therapy: laser therapy is usually used for eye melanoma that cannot be treated by surgery or radiotherapy. 6. Biological immunotherapy: The purpose of biological interleukin therapy is mainly to enhance the immune function and shrink advanced melanoma. Drugs such as atezolizumab and nabulizumab can make melanoma be recognized and attacked by the immune system normally. Skin breakouts, pain, touching lumps, and accelerated growth of existing moles, it is recommended to visit the dermatology and oncology departments of hospitals in a timely manner to look for the causes, and early detection and early treatment is expected to lead to a cure.