Hard bumps formed by acne on the sides of the cheeks may be a manifestation of severe acne forming nodules or scarring. Acne is a very common chronic inflammatory disease of the sebaceous glands of the hair follicles, occurring on the cheeks, forehead and jaw, and is often characterized by pimples, papules, pustules, nodules, cysts and scarring. Therefore, hard bumps on both sides of acne may be the result of more severe acne, which produces acne nodules manifesting as hard and painful lumps on the surface of the skin. It may also be due to the fact that after squeezing acne with the patient’s hands, scar tissue is formed due to localized infection or damage to the deeper tissues, which eventually develops. Patients are advised not to squeeze acne with their hands, and should pay attention to hygiene and use medications such as retinoic acid cream or fusidic acid cream and oral isotretinoin under the guidance of a doctor for treatment. Don’t stay up late, keep a regular schedule, and eat a light diet.