Premature Ovarian Failure (POF) refers to the loss of ovarian function in women before the age of 40. The cause of premature ovarian failure is still unclear, and it may be related to family genetics and autoimmune diseases, such as systemic lupus erythematosus, myasthenia gravis, hypoparathyroidism, and so on. In the early stage of the disease, patients mainly have abnormal menstruation, such as scanty or frequent menstruation, and then menstruation will gradually stop. Some patients have regular menstruation on weekdays, which may stop suddenly. There may also be vaginal dryness, recurrent vaginitis, urinary tract infection and other symptoms. There may also be insomnia, easy sweating at night and memory loss. It is recommended that patients with the above symptoms should seek timely medical treatment, complete relevant examinations, make a clear diagnosis under the guidance of specialized doctors, and carry out targeted treatment to avoid the impact of the disease on daily life.