In the vast majority of cases, children with fever suppositories will have an effect about 40-60 minutes after the medication is administered. Most of the fever suppositories are made of acetaminophen, ibuprofen and other non-steroidal anti-inflammatory drugs, which can effectively lower the temperature regulating point of children and cause the fever to subside, and it takes about 40 minutes for the drug to take effect. When applying fever suppositories to children, it is important to supplement with more water or apply oral rehydration salts to children in time, because oral rehydration salts also include sodium chloride and potassium, which can play a better purpose of reducing fever.