The difference between psoriasis and neurodermatitis includes different etiology and different clinical manifestations. 1. Different etiology: the etiology of psoriasis is still unclear, and it is currently believed that psoriasis is under the joint action of genetic factors and environmental factors, which ultimately leads to the occurrence or exacerbation of the disease; the etiology and pathogenesis of neurodermatitis are not yet clear, and it may be related to the following internal and external factors, among which local stimulation and mental and nervous factors may induce or exacerbate the disease. 2. Different clinical manifestations: the clinical manifestations of psoriasis are more, there are common type, arthropathy type, pustular type and erythroderma type, different types of psoriasis manifestations are different, such as common type psoriasis initial lesions for red papules, gradual expansion can appear in a variety of forms such as droplet, plaque, etc.; Neurodermatitis is generally manifested as flat papules fused into the symptoms of mossy lesions. It is recommended that patients go to the dermatology department of a regular hospital for a clear diagnosis and follow the doctor’s instructions for medication, not blindly self-medication.