Pancreatic plasma cysts have a very low chance of developing malignancy, and rare cases of malignant plasma cystadenoma have been reported. Pancreatic plasma cystic tumors are more common in females, mostly in the tail of the pancreas. Mostly benign and rarely malignant, they are mostly microcystic adenomas, typically presenting as honeycomb-like structures. The cystic fluid is characterized by clear, no mucus component, rich in glycogen, low carcinoembryonic antigen and tumor-associated antigen. One third of patients with pancreatic plasma cysts are asymptomatic. Common symptoms are abdominal pain and a palpable abdominal mass. Patients with asymptomatic, small lesions, less than 3 cm, of pancreatic plasma cystic tumors can be observed with regular imaging. Malignant cysts are usually larger in size, even up to 10 cm or more in diameter. Patients with a postoperative pathologic diagnosis of pancreatic plasmacytoid cystic tumor have an overall better prognosis, with a five-year survival rate of 100%.