The pain characteristics of gallbladder stones are related to the size and location of the gallstones. The typical features are mainly paroxysmal pain located in the middle and upper abdomen or right upper abdomen, or persistent dull pain with paroxysmal worsening. The pain may sometimes radiate to the interscapular region or the right shoulder. Also if there are large stones persistently embedded and compressed in the abdomen and neck of the gallbladder jugular, it may lead to recurrent attacks of cholecystitis, cholangitis and obstructive jaundice. Repeated irritation of gallbladder stones inducing acute cholecystitis may be accompanied by abdominal pain with nausea and vomiting. If small gallbladder stones drain into the bile duct causing obstruction of the common bile duct, they may cause acute cholangitis or pancreatitis, which usually manifests as persistent abdominal pain, chills, jaundice, and high fever. Gallbladder stones may also occur without any symptoms when they are in the gallbladder or with only mild epigastric discomfort, often detected during a physical examination. Patients with no symptoms or milder symptoms of gallstones can be treated with oral medications. If a gallbladder stone reaches the neck of the gallbladder and becomes obstructed, it can cause severe pain. When the location of the gallbladder stone changes, the obstruction is relieved and the painful symptoms are reduced. Repeated obstruction of gallstones induces inflammation, which may induce gallbladder cancer if stimulated for a long time, so patients with severe symptoms or frequent gallstones should consider active surgical treatment.