Herpesvirus type II IgM antibody positivity can be treated with oral or topical antiviral medications such as acyclovir and secondary infections by applying antibiotic ointment such as fusidic acid cream. 1. Antiviral drugs. Positive herpesvirus type 2 IgM antibody usually indicates recent infection and requires antiviral treatment, such as oral acyclovir, vasiclovir, etc. Acyclovir ointment, penciclovir cream, etc., or injections of acyclovir can be used for severe infections or extensive skin lesions. 2. Antibiotic ointment. If secondary bacterial infection occurs, fusidic acid cream, mupirocin ointment, etc. can be applied for treatment. When suffering from herpesvirus type 2 infection, you should choose the appropriate medication for treatment under the guidance of your doctor, and should not use the medication on your own.