Tumor Biotherapy Tumor biotherapy is an emerging tumor treatment mode with significant efficacy, which is a new type of autoimmune anti-cancer treatment method. It is a method to stimulate and enhance the autoimmune function of the body by using biotechnology and biological agents to culture and expand immune cells collected from patients in vitro and then transfuse them back into the patient’s body, so as to achieve the purpose of treating tumors. Tumor biotherapy is the fourth major tumor treatment technology after surgery, radiotherapy and chemotherapy. Treatment Principle The immune system is the defense system of human body, which plays the function of removing bacteria, viruses and foreign substances on one hand, and eliminating aging cells and mutated cells (some mutated cells will become cancer cells) on the other hand. The result of the interaction between the body’s immune system and cancer cells determines the final evolution of cancer. For a healthy person, his immune system is strong enough to remove mutated cancer cells in time. However, for cancer patients, the immune system is generally low and cannot effectively identify and kill cancer cells; on the other hand, the proliferation of cancer cells will further suppress the immune function of patients, and, cancer cells have multiple mechanisms to escape from the recognition and killing of immune cells. Immunotherapy for cancer is to improve the immunogenicity of cancer with the help of molecular biology technology and cell engineering technology, and to give the organism Immunotherapy for cancer is to enhance the immunogenicity of cancer, replenish the body with sufficient number of normal functioning immune cells and related molecules, stimulate and enhance the body’s anti-tumor immune response, increase the sensitivity of cancer to the body’s anti-cancer immune effect, induce cancer-specific and non-specific taste effector cells and molecules in vivo and externally, and achieve the ultimate purpose of cancer clearance. Cancer biotherapy, its effect is not to kill all cancer cells, but to treat cancer by removing tiny residual lesions or significantly inhibiting the proliferation of residual cancer cells due to the recovery of the body’s immune function when the cancer cell load is significantly reduced. Cancer immunotherapy is precisely to mobilize the body’s own immune system to kill and inhibit the proliferation of cancer cells through human intervention. After the primary cancer is surgically removed or the local cancer is ablated by minimally invasive surgery such as argon fluoride knife, immunotherapy can kill the remaining cancer cells, eliminate the factors of recurrence and metastasis, increase the possibility of cure, prolong the survival time and improve the quality of life. Currently, cancer biotherapy has been regarded as the fourth treatment method after surgery, radiotherapy and chemotherapy. Biological therapies include cytokine therapy, immune cell therapy, gene therapy, molecular targeting therapy and antibody therapy, etc. The treatment method I. Active immunotherapy The experts of CTC tumor biotherapy of New Bridge Hospital introduce that we collect peripheral blood from patients, isolate the factors that can activate the anti-tumor cells in patients’ own body, and then culture, modify and proliferate them in vitro and return them to patients’ body, which can rapidly stimulate and enhance the body’s own anti-cancer ability. DC cell therapy belongs to this category. 2. Relay immunotherapy The naturally existing anti-cancer cells in the patient’s body are isolated, activated in vitro, proliferated and then directly injected into the patient’s body to fight against tumors, which is equivalent to cultivating a powerful anti-cancer army for the patient. Cytokine-InducedKiller (CIK) cells fall into this therapeutic category. In clinical treatment, we will adjust the specific treatment plan according to the patient’s condition. For example, the combined DC-CIK treatment plan is a treatment plan with better efficacy that we have found in many clinical practice comparisons. Treatment advantages Biological cell immunotherapy is the fourth major tumor treatment technology after surgery, radiotherapy and chemotherapy. Biological cell immunotherapy has the following advantages in the treatment of tumors: 1. For some cancers, the efficiency is as high as 70%. 2. No toxic side effects of radiotherapy and chemotherapy, no pain for patients, good tolerance and strong specificity of tumor killing. 3. It can stimulate the systemic anti-cancer effect and is equally effective for multiple foci or metastatic malignant tumors. 4. It can help the body to quickly restore the anti-cancer immune system destroyed by radiotherapy and chemotherapy and improve the long-term anti-cancer ability. 5. It is effective in preventing recurrence of cancer after surgery and has good long-term anti-cancer effect. It can be used alone or in combination with other treatment methods. It is effective for single use and better for multiple use. DC+CIK cell immunotherapy DC+CIK cell immunotherapy is to culture stem cells in vitro, induce their differentiation into dendritic cells, and then induce CIK cells with antigen-stimulated dendritic cells to produce specific tumor-killing effects. DCs are the most powerful antigen-presenting cells discovered to date (i.e., they provide tumor-related information to cells with tumor-killing activity that normally exist in the human body) and play a role similar to a “radar” in the human immune system; CIK is a class of peripheral blood single nuclei cells that are induced in vitro by a combination of cytokines. CIK is a heterogeneous population of CD3+ CD56+ T cells, which are the main effector cells of peripheral blood mononuclear cells, which are induced by various cytokines in vitro, and therefore have the effects of both T cells and NK cells, which are the main anti-tumor active cells in human body, and their in vitro anti-tumor activity is 100-1000 times stronger than that of LAK, CTL and TIL cultured in previous biotherapies. Medical doctors describe it more graphically as: if T cells act as a “cannonball” in the human immune system, CIK is equivalent to a more powerful “missile”. The CIK cells can recognize the tumor cells by different mechanisms, through direct cytoplasmic particles to penetrate the closed tumor cell membrane, to achieve the lysis of tumor cells; Second, by inducing apoptosis of tumor cells to kill tumor cells; Third, CIK cells secrete IL-2, IL-6, IFN-γ and other anti-tumor cytokines; Fourth, CIK cells can be transfused back to activate the body’s Immune system and improve the immune function of the body. The combined application of DC+CIK cell therapy will achieve the efficacy of “1+1>2”, which can significantly inhibit the growth and proliferation of tumor cells, significantly improve the quality of life of patients, and enhance the survival of tumor patients, which is a new and more effective means after tumor surgery, radiotherapy and chemotherapy. This therapy can be used alone or as a powerful adjuvant after surgery, chemotherapy and radiotherapy with remarkable effect. Combined with surgical resection, intervention, radiofrequency, argon helium knife and other treatments, it can remove the very small tumor foci that cannot be removed by surgery or the tumor cells scattered in the body, and has an important role in delaying or stopping the metastasis or recurrence of tumor; for some tumor patients who are temporarily not suitable for surgery, intervention or other treatments, they can also undergo DC+CIK cell therapy first to improve their physical function, improve their quality of life and strive for other treatment opportunities. For some tumor patients who are temporarily suitable for surgery, intervention or other treatments, DC+CIK cell therapy can also be performed first to improve their physical function, improve their quality of life and strive for other treatment opportunities. Because biological immunotherapy technology uses human body’s own immune cells instead of traditional chemicals to kill tumor cells, it is safe and non-toxic, and is applicable to all stages of cancer treatment, and has relieved countless cancer patients of their pain and brought them health benefits since its implementation! Tumor biotherapy is the latest tumor treatment technology that is superior to surgery, radiotherapy and chemotherapy. It is a treatment method to cultivate auto-immune cells that can kill tumor through biotechnology in a high-standard laboratory, and transfuse them back into the body to kill cancer cells directly. Unlike traditional treatment methods, tumor biotherapy directly identifies and destroys cancer cells existing in the blood and lymph of human body without damaging the immune system and functions of the body, and restores and enhances the natural anti-cancer immune system and functions of the body. Biological tumor therapy has the advantages of being non-invasive, painless, without hospitalization, etc. It can improve patients’ own immunity and quality of life, and is applicable to all tumor diseases, and this biological therapy technology has been officially applied in clinical practice. The biotherapy technology has been officially applied in clinical practice. It can prevent tumor recurrence and metastasis for tumor patients after surgery; for patients with middle and late stage tumor who cannot undergo surgery, radiotherapy or chemotherapy; for tumor patients who have failed radiotherapy or chemotherapy; for comprehensive treatment of tumor patients after radiotherapy or chemotherapy, which can reduce the side effects of radiotherapy or chemotherapy; for leukemia patients after bone marrow transplantation or chemotherapy remission; for patients with cancerous thoracic or abdominal effusion; for patients who are temporarily unsuitable for surgery, intervention or other treatments. Patients. Facing the rapid and diversified development of tumor treatment technology, more and more patients choose to apply immune cell therapy technology, so what kind of people are most suitable for immune cell therapy? One third of early-stage tumors can be cured by immune cell therapy, so is immune cell therapy only applicable to early-stage tumor patients? Can older patients undergo immune cell therapy? Can patients who are inoperable or failed in radiotherapy have immune cell therapy? In fact, immune cell therapy is not only applicable to the treatment of early stage tumor patients, but also a few advanced tumor patients can achieve partial or complete remission after immune cell therapy. And because this treatment has no toxic side effects, it is also the best choice for those patients who are older, have poor body immunity and are afraid of toxic side effects of radiotherapy. Meanwhile, for those who are not sensitive to radiotherapy or cannot tolerate radiotherapy, and for some advanced tumor patients who are not suitable for surgery, interventional therapy and other treatments, cellular immunotherapy can improve the immune function of patients, improve the quality of life and prolong the survival period with tumor; some patients can significantly reduce the size of tumor through immune cell therapy and strive for surgery or other treatment opportunities.