Patients’ foot cramps at night are commonly caused by overexertion or muscle cold, hypocalcemia, osteoporosis, as follows: First, overexertion or muscle cold: overexertion or muscle cold can lead to clinical symptoms of foot cramps in patients at night, accompanied by local pain. After timely massage, hot compress and reverse stretching, the muscle spasm and tension can be released and the pain symptoms can be relieved. Second, hypocalcemia, osteoporosis: patients with hypocalcemia and osteoporosis can cause the symptoms of foot cramps at night, and can be accompanied by a feeling of numbness around the patient’s mouth, laboratory tests of serum calcium ions, the concentration will be significantly reduced, bone density will also be significantly reduced. Patients with foot cramps at night should be diagnosed and treated promptly, and the corresponding treatment methods should be chosen according to the different causes, which can lead to rapid relief of symptoms. Usually, one should also pay attention to keeping warm, avoiding cold, avoiding overexertion, fighting osteoporosis, exercising in moderation, and preventing hypocalcemia in life.