Taking engeletin to lose a lot of weight may be caused by increased urinary glucose excretion after using the drug, or it may be caused by other diseases such as hyperthyroidism and tuberculosis. Engeletin belongs to the sodium-glucose cotransporter 2 inhibitor, can be used in the treatment of type 2 diabetes mellitus, can reduce the glucose reabsorption of the kidney, play a role in lowering the renal glucose threshold as well as to promote glucose from the urinary discharge, and ultimately play a role in lowering the purpose of blood glucose. Therefore, after long-term treatment with empagliflozin, it will increase the excretion of calories, which in turn will reduce body weight and appear to lose a lot of weight. In addition, very thin can also be seen in some consumptive diseases, such as hyperthyroidism, tuberculosis, malignant tumors, etc.; and, diabetic patients with poor glycemic control itself can also cause thinning. Adverse reactions such as hypotension, ketoacidosis, acute kidney injury, hypoglycemia, etc. may also occur after taking engelezine. It is contraindicated in patients with a history of severe hypersensitivity reaction to engeletin, severe renal impairment, end-stage renal disease or dialysis. It is recommended to go to the hospital and ask the doctor to make a judgment if you have lost a lot of weight after treatment with Engeletin.