According to the CDC, the number of rabies deaths in China in 2014 was 854 cases, and in 2013 it was 1128 cases. Many netizens are most concerned about which contacts require vaccination. Rabies, also known as hydrophobia and rabies, is an acute infectious disease of humans and animals caused by the rabies virus, with a mortality rate of almost 100%. Some countries or regions are rabies-free or rarely occur due to their unique geographic environment (e.g., Japan, Australia, and other island countries) or due to strict protective measures. However, in Africa, Asia and Latin America, the rabies epidemic is still relatively serious. A 2010 survey showed that the number of rabies deaths worldwide is between 26,400 and 61,000 per year, with the number of rabies deaths in Asia ranking first in the world, and China is a country with a high incidence of rabies. Historically, China is one of the earliest countries in the world to document this disease. In the Spring and Autumn Period, the record of the state chasing mad dogs was recorded in the Seventeenth Year of Lord Xiang. In the Western Han Dynasty, Liu An, the king of Huainan, compiled the “Huainanzi? This is the earliest recorded case of death by rabid dog bite in the history of China. Under natural conditions, the main susceptible animals are canines, cats, ferrets, raccoons, rodents and pterodactyls, such as dogs, cats, foxes, wolves, jackals, leopards, raccoons, B, ferrets and bats. In countries with serious rabies epidemics, such as Asia and Africa, dogs and cats are the most commonly transmitted animals, and more than 90% of rabies cases worldwide are caused by dogs infected with the virus. The vast majority of rabies cases in China are caused by dogs or cats, with dogs in particular being the most numerous. Cold-blooded animals such as turtles and snakes do not transmit rabies virus, and there have been no reports of rabies virus transmission from chickens or birds, and rabies exposure management is not required after being bitten or scratched by birds or chickens, but wound management is required. The WHO recommended first aid procedures for patients exposed to animals with suspected/confirmed rabies include immediate and thorough rinsing and washing of the wound with soap and water, detergent, iodophor, or other substances with virucidal activity; this is followed by different treatment measures depending on the severity of the injury classification. Level I: contact with or feeding of animals, intact skin in contact with secretions or excretions of rabid animals or humans, no prophylaxis required. Grade II: light bites on bare skin, minor scratches or abrasions without bleeding, requiring treatment of the wound, while vaccination should be given as soon as possible. Grade III: single or multiple bites or scratches through the skin, broken skin licked, or mucous membranes contaminated with animal body fluids, then the wound should be treated immediately, a passive rabies immunization preparation should be administered, and rabies vaccination should be given. Of course, the most important post-exposure prophylaxis is wound treatment, followed by vaccination, which must be done as soon as possible. The recommended regimen is a 5-dose regimen and a 4-dose regimen. 5-dose regimen is one dose each on days 0, 3, 7, 14, and 28, with day 0 being the time of the first vaccination. 4-dose regimen is 0, 7, 21, and three times, but the first injection is two doses of vaccine. WHO recommends inactivated rabies vaccine. Millions of people worldwide have received this vaccine after or before exposure, and it has been shown to be safe and effective. Common adverse reactions reported overseas include a mild transient rash, pain or swelling at the injection site, especially after intradermal boosters, and mild systemic adverse reactions, such as transient fever, headache, dizziness and gastrointestinal symptoms, in about 10% of the vaccinated population. Serious adverse reactions are very rare, including Guille-Barre syndrome and allergic reactions. In contrast, fever was the most common adverse reaction to vaccination in China. The study also found that the occurrence of adverse reactions after vaccination was related to age, vaccination procedure, wound level, and the type of animal injured. 2-1-1 vaccination procedure, low age, grade II wounds, and adverse reactions due to cat injury were significantly higher in the vaccinated population. It is suggested that the immune response ability of vaccine recipients and vaccine dose may be important factors affecting the safety and tolerability of the vaccine. Theoretically, vaccination according to the procedure can provide lifelong protection due to the presence of immune memory, but according to the requirements of the World Health Organization and China’s CDC, re-evaluation of vaccine booster is still required after re-exposure. In summary, as long as the skin is intact, exposure to a suspected or confirmed sick dog should be vaccinated. This answers the first question at the beginning, but the difficulty is what kind of dog is a suspected or confirmed rabid dog? A confirmed dog is easy to understand, but what about a suspected dog? What about a healthy dog that is domesticated? The ability of healthy dogs to transmit rabies has been debated internationally for at least 50 years. In the past 10 years or so, some researchers in China have detected or isolated rabies virus in the brain tissue of apparently healthy dogs and also believe that healthy dogs can transmit rabies virus, a view that has had a significant impact on people injured by dogs. a technical report issued by the World Health Organization’s Expert Consultation on Rabies in 2004 stated that “a dog or cat that injures a person and remains healthy for at least 10 days after the exposure occurs It is possible to terminate post-exposure prophylaxis in humans.” Foreign studies have shown that rabies virus can be detected in the saliva of dogs 3 days before the onset of clinical signs of rabies; 75% of dogs with rabies survive for only 4 days, and all dogs with rabies die within 10 days of the onset of clinical signs. Therefore, prompt access to a canine injury clinic is required for proper post-exposure prophylaxis after injury by a canine animal. However, if a person is still healthy and free of abnormalities after 10 days of exposure, it is believed that the chances of a person contracting rabies virus are almost zero.