Numbness in the hands and feet can be caused by many reasons, as follows: first, neurological diseases, sudden onset of persistent numbness on one side of the hands and feet, can be seen in middle-aged and elderly patients with hypertension, coronary heart disease, diabetes, suggesting acute cerebrovascular disease, should be consulted as soon as possible in the neurological emergency. Second, endocrine diseases, diabetes patients with long-term higher than normal blood glucose, will affect the peripheral nerves, resulting in patients with diabetic peripheral neuropathy, involving the end of the hands and feet, the feeling will have numbness symptoms, when the electromyography can be clearly diagnosed. Third, local strain disease, due to excessive strain or strain, resulting in tendon injury, as well as compression of nerves, causing impaired blood circulation, will also appear numbness. Through recuperation and local physical therapy can be alleviated, or oral vitamin B and other nerve-nourishing drugs can be restored.