Diffuse thyroid lesion with breath-holding needs to complete relevant examinations to clarify the presence of hyperthyroidism, hypothyroidism, thyroid cancer and other diseases, and under the guidance of the doctor to choose drugs, surgery, radioactive iodine and other treatments according to the condition. Diffuse thyroid lesion is the description of thyroid ultrasound and other imaging tests, suggesting that there may be thyroid function abnormalities, there may be hyperthyroidism or hypothyroidism. Feeling breathless suggests the presence of an enlarged thyroid gland compressing the trachea causing dyspnea. Further thyroid function tests should be performed, and thyroid puncture biopsy should be performed if necessary to clarify the etiology. If hyperthyroidism is caused by diffuse toxic goiter, there are surgical indications for breathlessness. Diffuse thyroid lesions with breath-holding is recommended to consult a doctor to find out the cause of the disease and treat it as soon as possible under the doctor’s guidance to avoid delaying the disease.