Hypofractionated biliary hepatocellular carcinoma indicates a relatively high degree of malignancy, and treatment options include surgical treatment and neoadjuvant chemotherapy. Hypofractionated bile duct hepatocellular carcinoma is graded as grade III in pathology, which often represents a relatively high degree of malignancy and is prone to progress and metastasis in the course of disease development. 1. Surgical resection: this method is the first choice of treatment for cholangiocellular carcinoma. The effect of surgery is related to the location of tumor, the degree of tumor infiltration and whether there is lymph node metastasis. For patients who cannot be surgically resected, neoadjuvant chemotherapy should be carried out first to make the tumor downstage and shrink, so as to increase the chance of radical surgical resection. 2. If patients with bile duct hepatocellular carcinoma have biliary obstruction and the tumor cannot be resected, biliary stent should be put in to drain bile, relieve symptoms and improve survival rate. 3. For complicated hepatoportal tumors, endoscopic retrograde cholangiopancreatography with nasal conduit drainage or percutaneous biliary drainage can be used. This type of disease is not sensitive to radiotherapy and chemotherapy, and surgical treatment is still the most effective means to treat biliary hepatocellular carcinoma. If the above diseases are diagnosed, it is recommended to go to the hospital in time for early and regular treatment.