Primary biliary cholangitis is an autoimmune disease that cannot be cured, but only slowed down by appropriate treatment. Primary biliary cholangitis, also known as primary biliary cirrhosis, is caused by damage to the bile ducts due to abnormalities in the body’s humoral and cellular immunity. There are no drugs that can block this immune damage. Patients may experience jaundice, itching, and weakness due to cholestasis. In later stages, fat digestion and absorption, rough skin, night blindness, osteoporosis and other manifestations may occur due to cirrhosis caused by cholestasis. The current treatment is mainly to use ursodeoxycholic acid, which can increase the secretion of bile acids and weaken the cytotoxicity of bile acids thus protecting the bile duct cells and hepatocytes. Treatment with budesonide and obeticholic acid may be considered in patients for whom ursodeoxycholic acid treatment is ineffective, helping to reduce the local inflammatory response and cellular damage. Patients with primary biliary cholangitis should go to the hospital in a timely manner and use the correct medication under the doctor’s supervision to slow down the disease process.