Spots on hands are mainly seen in age spots, freckles and so on, and the ways of removing them mainly include laser treatment, freezing treatment, surgical treatment, and supplemented with medication and so on. 1. Treatment methods of age spots: Laser treatment includes Q-switched Nd:YAG laser and Q-switched ruby laser, and strict sun protection is needed after treatment to avoid pigmentation. Cryotherapy is easy to operate, but it requires several times of treatment, and the local area may have the risk of remaining hyperpigmentation. 2. Treatment of freckles: Q-switched Nd:YAG laser and Q-switched ruby laser in laser treatment are also effective in removing freckles, and it is necessary to pay attention to strengthening skin care after the operation. Medication: Topical topical decolorizing agent (3% hydroquinone cream) as well as retinoids (0.05%~0.1% retinoic acid cream) can help improve the symptoms of freckles. Trichloroacetic acid solution or phenol spot-coating also helps to improve the symptoms of freckles, but the side effects are larger and are rarely used clinically. Due to the different types of pigmentation, there are slight differences in treatment, and the specific situation needs to go to a regular medical institution and ask for a doctor’s consultation first.