Nerve block refers to blocking the vicious cycle of pain, reducing the sensitivity of peripheral and central nervous system, eliminating inflammation, reducing edema, relaxing muscles, and improving local blood circulation, accelerating the metabolism of pain-causing substances, and promoting the repair of damaged nerves, thus relieving or alleviating pain. It is a drug injection according to the route and innervation of nerves. The drugs used are more reasonable, more extensive and safer. The scope of application is broader, not only for clinical analgesia and treatment, but also for diagnosis, prognosis and disease prevention. It is also more difficult, complicated and precise to operate, and it is applicable to various painful diseases and some non-painful diseases. Sequestration therapy originated in the former Soviet Union, which is the injection of drugs into the local pain points of the body to play a role in pain relief, and can be simply understood as where to hit where it hurts. The two are completely unrelated two concepts, but also two very different treatment methods, nerve block therapy as the most basic means of pain treatment, can fully play a greater role for the majority of pain patients to relieve the tangible pain. 1, the use of different drugs “closed” generally use a higher concentration of drugs, while “nerve block” using a lower concentration of drugs can achieve the therapeutic effect, so there will be no limb and the whole body to produce adverse reactions. 2, the site of the different closure of the injection of drugs is the site of pain, equivalent to the target area of the nerve block block, nerve block is according to the nerve travel and innervation of the law of drug injection, such as the commonly used clinical stellate ganglion block, the treatment site is in the neck, but can treat neurasthenia, insomnia, sympathetic cervical spondylosis, hypertension, facial paralysis and a dozen other difficult diseases. 3, the technical difficulty and efficacy of the operation of different “closed” is only the injection of drugs to the proximal end of the lesion or nearby to achieve the purpose, or even “which pain hit which”, the accuracy requirements are not high. While “nerve block” is a technical operation that must undergo a long period of professional training to implement correctly, the heart must be injected accurately into or around the lesion tissue, in order to achieve the desired effect of treatment. 4, the different requirements for diagnosis “closed” therapy is based on pain closure to block the pain arc continued, the diagnosis before injection is not necessarily clear, the injection site is not necessarily the lesion, so the diagnosis is not clear can also be carried out, often pain relief but the lesion can still have development. In contrast, before administering “nerve block” therapy, the diagnosis must be clear and the location of the lesion must be understood, and the drug must be injected into the lesion. Therefore, the efficacy of the two treatments cannot be compared to each other. The characteristic of “nerve block” therapy is that “the most needed drugs are delivered in the most direct way, to the most accurate place”. Therefore, “nerve block” is a non-surgical treatment method that concentrates the advantages of medicine and fights a war of annihilation and rapid warfare, with fast results and high efficacy, and fewer visits to the hospital by patients. As a result, they are two completely unrelated concepts and two very different treatment methods. As the most basic means of pain treatment, nerve block therapy can play a greater role in relieving the personal pain for the majority of pain patients.